As someone whose job is to relieve people’s pain, understanding the science of pain is obviously very important. But pain isn’t necessarily easy to understand. If tissue is damaged in the body, it sends a signal to the brain and then we hurt, right? So if we fix the tissue located in the painful spot, then the pain goes away, right? While this is sometimes true, there is a big misunderstanding of pain by both patients and even some practitioners who are attempting to treat their patient’s pain.
Let’s begin with a simple explanation of pain, because when we understand pain, we no longer have to fear it. In the introduction of the book, Explain Pain, which I highly recommend, physiotherapist David Butler and Lorimer Moseley, PhD, explain pain as an unpleasant feeling that is essential to life because it protects us and alerts us to danger. When this happens, it changes how our muscles and joints function, our thoughts and behaviors, and it can even affect our immune system.
However, as you will soon learn, the amount of pain we feel DOES NOT necessarily relate to the amount of tissue damage. In fact, many sensory cues come together to form a pain experience. Unfortunately, it is not as simple as a nerve innervates a tissue, the tissue is damaged, we feel pain, and then we heal tissue and we no longer have pain.
For example, maybe you have heard of a story or experienced first hand a fairly severe injury that didn’t hurt immediately. Maybe you were playing in a big sporting event and after the game you noticed a sore spot. Or maybe you’ve heard stories of soldiers being shot in battle and never realizing it until the battle was over. On the other hand, why do paper cuts hurt so bad when there is barely any damage at all? Obviously, the idea of “damaged-nerve sends signal to brain and then pain happens” doesn’t fit.
What is actually happening during a pain experience is much more complicated. As we know, to begin there is usually damage to a tissue, joint, etc. The nerves innervating those tissues are activated and send a signal. However, once the signal enters the spinal cord and brain, aka the central nervous system, things are a bit different than we assume. At this point it is up to the brain to decide if it is appropriate to construct a pain experience or not. Things that affect this may include: thoughts, beliefs, job situation, home situation, mood, past pain experiences, and so on.
The most interesting example to me is that of phantom limb pain. This often occurs in people who have lost an arm or leg but still get pain in that arm or leg. This alone proves pain is not only in the tissue (Norman Doidge, The Brain That Changes Itself). So for those who believe that there must be damaged tissue to have pain, think again. Pain is in the brain.
Now that we know pain is in our head, please know that I am NOT in anyway saying that it isn’t real because it most definitely is! In fact, a person who says it isn’t doesn’t truly understand pain at all. How can more than one billion people suffering from chronic pain be wrong? (Butler and Mosley).
Another subject that affects a pain experience that I would like to mention is that of imaging such as MRIs or x-rays. While they can be very informative and often necessary to rule out serious diseases such as cancer, it is very important that we do not fear what they show. This means that an x-ray might show some degenerative changes, or an MRI may show a slightly herniated disc, when in reality this is more the norm than the exception. After the age of 25, most of us will have some NORMAL degenerative changes. One study showed that up to 35% of people who have never experienced low back pain had herniated discs (Weishaupt D et al). Instead of dwelling on what was seen on the image, we should be more concerned about dysfunctional joints and muscles. Maybe it’s bad posture, joint restriction, poor lifting habits, or instability that needs rehabilitation. Once these dysfunctions (the true causes of pain) are addressed one will see the pain diminish. And once we realize a herniated disc can be completely functional with normal body biomechanics, we no longer have to fear it!
So how can we relate this to every day pain suffers? Well, imagine a person who sits at a desk all day and gets very little movement throughout the day, has poor posture, and holds a lot of tension in his or her shoulders. While there is no immediate pain, this can actually cause a build up of acid in the muscles (Butler and Mosely) and with enough build up, the nerve sensors open up and send a signal to the cord and then to the brain where it decides if it is a danger or not. If you have had a terrible day, and you are ready to go home the pain will probably be increased, whereas if you are focused on something very important and enjoying the work then it may not be as noticeable. However, if the acid persists, it can definitely become dangerous, and we will experience pain.
Another example is when a person bends over to pick a pencil and his or her back goes out. The person can barely stand and is in excruciating pain. The second this happens our brain begins to process not only signals from the tissue, but all sorts of information. Is it broken? How can I still function? Will I miss the big game? How much will it cost? Etc. According to Butler and Mosely, all of these questions are being processed in the brain without us really even knowing it. All we know is that we hurt!
These last two examples relate to chronic and acute pain. Whenever there is some type of tissue injury, inflammation occurs to help healing, which is a good thing. However, if it persists it becomes a bad thing and our brain continues to sense danger, making it a persistent pain perception or chronic pain. (Following graph from Butler and Mosley).

When it comes to chronic pain, Butler and Mosely compare the brain to an orchestra. A really good orchestra has many different instruments playing many different tunes. They play many different songs and give great performances—like a good functioning body. Now, imagine this orchestra starts playing the same song over and over and over. Pretty soon, it can no longer play other tunes, nor can it be creative, curious, or seek new challenges. Instrumentalists quit, spectators become unhappy, and the tune is no longer a good one. In the brain when the pain perception is constant for too long—and poor muscle and joint function becomes the normal movement—it becomes the only tune we hear even in instances where the tissues are completely healed. Our brain becomes sensitized to pain (Doidge).
Notice the two ways we can fall into chronic pain. (Following graph from Butler and Mosley).

So how do we keep acute pain from becoming chronic, and if it is chronic pain how do we treat it? To begin, lets consider a person who just got into a minor car accident that hasn’t had a history of pain. However, after the accident they have pain in the neck and are sent to the emergency room. Imaging is done which shows degenerative changes. The patient is given a whiplash diagnoses sent home with some pain pills and never educated on the pain process. Now the person thinks of the imaging findings whenever turning their head and experiences pain because they think they are hurting the tissue. The muscles around the neck then begin to tighten to protect it and results in muscle imbalance and joint restriction. Now we have a system that is set up perfectly for chronic pain with both fear of pain and the muscle and joint problems that keep the pain experience going. However, if this person had a better understanding of pain and taken the appropriate steps to avoid excess inflammation and avoid creating muscle and joint imbalances it would have been quick to heal.
If the pain has become chronic, the answer lies in finding the true break down leading to pain. In this person’s case it is not the degenerative changes in the spine that are the problem, but the fear avoidance beliefs as well as the muscle imbalances around it and joint restrictions likely above and below it. Therefore, the treatment is not directed at the pain site but the beliefs and dysfunctions around it. Most commonly the cause of the pain is far from the site of pain. Karel Lewit, a very famous medical doctor says: “He who treats only at the site of pain is lost.” Therefore, once we treat these dysfunctions away from the site of pain, we will see relief of the pain.
To summarize, here are some basic tools I follow with my patients:
Tool 1: Education and understanding
- No pain, no gain = no good
- Let pain be your guide = no good
- UNDERSTAND PAIN = you don’t have to fear it
Tool 2: Your hurts won’t harm you
- Hurt does not always equal harm
- BUT WAIT! This certainly doesn’t mean go out and run a marathon!
- GRADUALLY increase activity
Tool 3: Pacing and graded exposure
- Movement is essential for health (motion is lotion)
- Find what you want to do more of—find a baseline and plan a progression
Tool 4: Accessing the virtual body
- Imagined movements
- Alter gravitational forces
- Alter environmental activities
- Add distractions
Understanding pain can be a great liberator. We should understand that the phrase, “No pain, no gain,” shouldn’t be our thought process, but we also shouldn’t let pain completely be our guide either. Butler and Mosely have the saying, “KNOW your pain, or no gain!” And aside of traumatic injury that requires direct treatment to the site, understanding the science of pain and treating the true dysfunctions away from the sight of pain have become the standard.
Resources
Butler, David S., and Mosley, C. Lorimer. Explain Pain, First Edition. Australia: Noigroup Publications, 2003.
Doidge, Norman. The Brain that Changes Itself. USA: Penguin Books, 2007.
Weishaupt D et al. “MRI of the lumbar spine: Prevalence of intervertebral disc extrusion and sequestration, nerve root compression and plate abnormalities and osteoarthritis of the fact joints in asymptomatic volunteers.” Radiology 1998, 209:661-666.